Lehninger Principles of Biochemistry By David L. Nelson

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    Lehninger
    Principles of Biochemistry
     
    David L. Nelson
    Michael M. Cox
     
    W. H. Freeman, Hardback, Fifth edition, 2008.
    4to. xxix, 1158 pp., G-17, C-8, A-4, AS-35, I-41.
     
    Fifth edition first published in 2008.
     
    Contents [somewhat in brief, necessarily]
     
    About the authors
    A Note on the Nature of Science
    Preface
     
    1. The Foundations of Biochemistry
    1.1. Cellular Foundations
    1.2. Chemical Foundations
    1.3. Physical Foundations
    1.4. Genetic Foundations
    1.5. Evolutionary Foundations
     
    I. STRUCTURE AND CATALYSIS
     
    2. Water
    2.1. Weak Interactions in Aqueous Solution
    2.2. Ionization of Water, Weak Acids, and Weak Bases
    2.3. Buffering against pH Changes in Biological systems
    2.4. Water as a Reactant
    2.5. The Fitness of the Aqueous Environment for Living Organisms
     
    3. Amino Acids, Peptides and Proteins
    3.1. Amino Acids
    3.2. Peptides and Proteins
    3.3. Working with Proteins
    3.4. The Structure of Proteins: Primary Structure
     
    4. The Three-Dimensional Structure of Proteins
    4.1. Overview of Protein Structure
    4.2. Protein Secondary Structure
    4.3. Protein Tertiary and Quaternary Structures
    4.4. Protein Denaturation and Folding
     
    5. Protein Function
    5.1. Reversible Binding of a Protein to a Ligand: Oxygen-Binding Proteins
    5.2. Complementary Interactions between Proteins and Ligands: The Immune System and Immunoglobulins
    5.3. Protein Interactions Modulated by Chemical Energy: Actin, Myosin, and Molecular Motors
     
    6. Enzymes
    6.1. An Introduction to Enzymes
    6.2. How Enzymes Work
    6.3. Enzyme Kinetics as an Approach to Understanding Mechanism
    6.4. Examples of Enzymatic Reactions
    6.5. Regulatory Enzymes
     
    7. Garbohydrates and Glycobiology
    7.1. Monosaccharides and Disaccharides
    7.2. Polysaccharides
    7.3. Glycoconjugates: Proteoglycans, Glycoproteins and Glycolipids
    7.4. Carbohydrates as Informational Molecules: The Sugar Code
    7.5. Working with Carbohydrates
     
    8. Nucleotides and Nucleic Acids
    8.1. Some Basics
    8.2. Nucleic Acid Structure
    8.3. Nucleic Acid Chemistry
    8.4. Other Functions of Nucleotides
     
    9. DNA-Based Information Technologies
    9.1. DNA Clonning: The Basics
    9.2. From Genes to Genomes
    9.3. From Genomes to Proteomes
    9.4. Genome Alterations and New Products of Biotechnology
     
    10. Lipids
    10.1. Storage Lipids
    10.2. Structural Lipids in Membranes
    10.3. Lipids as Signals, Cofactors, and Pigments
    10.4. Working with Lipids
     
    11. Biological Membranes and Transport
    11.1. The Composition and Architecture of Membranes
    11.2. Membrane Dynamics
    11.3. Solute Transport across Membranes
     
    12. Biosignaling
    12.1. General Features of Signal Transduction
    12.2. G Protein-Coupled Receptors and Second Messengers
    12.3. Receptor Tyrosine Kinases
    12.4. Receptor Guanylyl Cyclases, cGMP, and Protein Kinase G
    12.5. Multivalent Adaptor Proteins and Membrane Raffts
    12.6. Gated Ion Channels
    12.7. Integrins: Bidirectional Cell Adhesion Receptors
    12.8. Regulation of Transcription by Steroid Hormones
    12.9. Signaling in Microorganisms and Plants
    12.10. Sensory Transduction in Vision, Olfaction, and Gustation
    12.11. Regulation of the Cell Cycle by Protein Kinases
    12.12. Oncogenes, Tumor Supressor Genes, and Programmed Cell Death
     
    II BIOENERGETICS AND METABOLISM
     
    13. Bioenergetics and Biochemical Reaction Types
    13.1. Bioenergetics and Thermodynamics
    13.2. Chemical Logic and Common Biochemical Reactions
    13.3. Phosphoryl Group Transfer and ATP
    13.4. Biological Oxidation-Reduction Reactions
     
    14. Glycolysis, Gluconeogenesis, and the Pentose Phosphate Pathway
    14.1. Glycolysis
    14.2. Feeder Pathways for Glycolysis
    14.3. Fates of Pyruvate under Anaerobic Conditions: Fermentation
    14.4. Glugoneogenesis
    14.5. Pentose Phosphate Pathway of Glucose Oxidation
     
    15. Principles of Metabolic Regulation
    15.1. Regulation of Metabolic Pathways
    15.2. Analysis of Metabolic Control
    15.3. Coordinated Regulation of Glycolysis and Gluconeogenesis
    15.4. The Metabolism of Glycogen in Animals
    15.5. Coordinated Regulation of Glycogen Synthesis and Breakdown
     
    16. The Citric Acid Cycle
    16.1. Production of Acetyl-CoA (Activated Acetate)
    16.2. Reactions of the Citric Acid Cycle
    16.3. Regulation of the Citric Acid Cycle
    16.4. The Glyoxylate Cycle
     
    17. Fatty Acid Catabolism
    17.1. Digestion, Mobilization, and Transport of Fats
    17.2. Oxidation of Fatty Acids
    17.3. Ketone Bodies
     
    18. Amino Acid Oxidation and the Production of Urea
    18.1. Metabolic Fates of Amino Groups
    18.2. Nitrogen Excretion and the Urea Cycle
    18.3. Pathways of Amino Acid Degradation
     
    19. Oxidative Phosphorylation and Photophosphorylation
     
    OXIDATIVE PHOSPHORYLATION
    19.1. Electron-Transfer Reactions in Mitochondria
    19.2. ATP Synthesis
    19.3. Regulation of Oxidative Phosphorylation
    19.4. Mitochondria in Thermogenesis, Steroid Synthesis, and Apoptosis
    19.5. Mitochondrial Genes: Their Origin and the Effects of Mutations
     
    PHOTOSYNTHESIS: HARVESTING LIGHT ENERGY
    19.6. General Features of Photophosphorylation
    19.7. Light Absorption
    19.8. The Central Photochemical Event: Light-Driven Electron Flow
    19.9. ATP Synthesis by Photophosphorylation
    19.10. The Evolution of Oxygenic Photosynthesis
     
    20. Carbohydrate Biosynthesis in Plants and Bacteria
    20.1. Photosynthetic Carbohydrate Synthesis
    20.2. Photorespiration and the C4 and CAM Pathways
    20.3. Biosynthesis of Starch and Sucrose
    20.4. Synthesis of Cell Wall Polysaccharides: Plant Cellulose and Bacterial Peptidoglycan
    20.5. Integration of Carbohydrate Metabolism in the Plant Cell
     
    21. Lipid Biosynthesis
    21.1. Biosynthesis of Fatty Acids and Eicosanoids
    21.2. Biosynthesis of Triacylglycerols
    21.3. Biosynthesis of Membrane Phospholipids
    21.4. Biosynthesis of Cholesterol, Steroids, and Isoprenoids
     
    22. Biosynthesis of Amino Acids, Nucleotides, and Related Molecules
    22.1. Overview of Nitrogen Metabolism
    22.2. Biosynthesis of Amino Acids
    22.3. Molecules Derived from Amino Acids
    22.4. Biosynthesis and Degradation of Nucleotides
     
    23. Hormonal Regulation and Integration of Mammalian Metabolism
    23.1. Hormones: Diverse Structures for Diverse Functions
    23.2. Tissue-Specific Metabolism: The Division of Labour
    23.3. Hormonal Regulation of Fuel Metabolism
    23.4. Obesity and the Regulation of Body Mass
    23.5. Obesity, the Metabolic Syndrome, and Type 2 Diabetes
     
    III INFORMATIVE PATHWAYS
     
    24. Genes and Chromosomes
    24.1. Chromosomal Elements
    24.2. DNA Supercoiling
    24.3. The Structure of Chromosomes
     
    25. DNA Metabolism
    25.1. DNA Replication
    25.2. DNA Repair
    25.3. DNA Recombination
     
    26. RNA Metabolism
    26.1. DNA-Dependent Synthesis of RNA
    26.2. RNA Processing
    26.3. RNA-Dependent Synthesis of RNA and DNA
     
    27. Protein Metabolism
    27.1. The Genetic Code
    27.2. Protein Synthesis
    27.3. Protein Targeting and Degradation
     
    28. Regulation of Gene Expression
    28.1. Principles of Gene Regulation
    28.2. Regulation of Gene Expression in Bacteria
    28.3. Regulation of Gene Expression in Eukaryotes
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